HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 3-Methyl-5-(1-methyl-2(S)-pyrrolidinyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 1-(1-CBZ-2(S)-pyrrolidinyl)-1-buten-3-one oxime | HCID 86748737 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Methyl-5-(1-methyl-2(S)-pyrrolidinyl)isoxazole | HCID 119380 | — |
Reaction Steps
The Cbz-protected compound of step 23d is reacted with LAH in THF at 0° C. as described in Example 24 below, and the title compound is isolated in pure form by extraction with ethyl acetate and distillation under high vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05559242 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-2ee2430a8b474610a5f38b75440d01a9 |
| Source note | uspto-grants-1996_09 |