HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → (4-Chloropyridin-2-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 4-Chloropyridine-2-carboxylic acid | HCID 230890 | — |
| Edukt | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Edukt | 5-Fluoroindoline | HCID 2774463 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | (4-Chloropyridin-2-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone | HCID 58386740 | — |
Reaktionsschritte
174 mg (1.27 mmol) 5-fluoro-2,3-dihydro-1H-indole were added to 200.0 mg (1.27 mmol) 4-chloropyridine-2-carboxylic acid, 351 μL (2.50 mmol) triethylamine and 434.0 mg (1.35 mmol) TBTU in 3 mL DMF. The reaction mixture was stirred overnight at RT. Purification was carried out by preparative HPLC. The product fractions were combined and evaporated down i. vac.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08829006B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-2734c073f2eb46e681607cbaafcd9340 |
| Quellennotiz | uspto-grants-2014_09 |