HCID 19607765, compound → HCID 10297101, compound

HRID 745118Notes

Reaction equation

HRID 745118 reaction equation
[CH3:1][N:2]([CH3:24])[CH:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C:14](=[O:23])[C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][C:16]=2[CH3:22])[CH2:6][CH2:5][CH2:4]1>CO.C(OCC)C>[CH3:24][N:2]([CH3:1])[CH:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C:14](=[O:23])[C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:14](=[O:23])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[CH3:22])=[CH:17][C:16]=2[CH3:22])[CH2:6][CH2:5][CH2:4]1

Participants

3

Reactant 1

HCID 19607765HCID 19607765, compound

Product 1

HCID 10297101HCID 10297101, compoundYield 70.3%

Reagents, catalysts & solvents 1

HCID 21864698Diethyl ether methanolSolvent

Procedure

Using 5-dimethylamino-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (G) (1.00 g), 5-dimethylamino-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine (0.48 g) is obtained in the same manner as in Example 978 except that methanol/diethyl ether is used instead of ethyl acetate as recrystallization solvent, as white powder, m.p. 183°-185° C.

Sources & evidence

ORD record
ord-4c96b858c522483688504a804985c52c
Source dataset
uspto-grants-1996_09
Patent number
US05559230

Reaction notes

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