[3-[[(1,1-Dimethylethoxy)carbonyl]amino-2-hydroxy-4-phenylbutyl]amino-2-hydroxy-4-phenylbutyl]carbamic acid, phenylmethyl ester → Benzyl carbamate

HRID 745126Notes

Reaction equation

HRID 745126 reaction equation
CC(C)(OC(NC(C1C=CC=CC=1)CC(O)CNC(CC1C=CC=CC=1)C(O)C[NH:16][C:17](=[O:26])[O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=O)C>CO>[C:17](=[O:26])([O:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[NH2:16]

Participants

3

Reactant 1

HCID 86749866[3-[[(1,1-Dimethylethoxy)carbonyl]amino-2-hydroxy-4-phenylbutyl]amino-2-hydroxy-4-phenylbutyl]carbamic acid, phenylmethyl ester

Product 1

HCID 12136Benzyl carbamate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 186 was prepared as a colorless solid from a 1:1 mixture of 1b(i) and 1b(ii) by a procedure analogous to that used for the synthesis of Compound 185d. mp 90°-95° C.; [α]D =-4.0° (c 0.10, MeOH). MS: (M+H)+ @578+Analysis calc. for C33H43N3O6. 0.9 6H2O:

Sources & evidence

ORD record
ord-4bf5838f199d4ac688cd98f8662ef2f4
Source dataset
uspto-grants-1996_09
Patent number
US05559256

Reaction notes

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