反应详情

At 170° C. 3.0 g (20 mmol) 5-fluoroindolinone were stirred for 3 h in 10 mL (98 mmol) acetic anhydride. After cooling to RT the mixture was poured onto 200 mL ice water, the precipitated substance was suction filtered and washed with 100 mL water. The solid was recrystallised from 100 mL water and 50 mL ethanol at boiling temperature. The precipitated product was suction filtered, washed with 30 mL water and dried in the CAD.

1. customAt 170° C
2. filtrationfiltered
3. washwashed with 100 mL water
4. customThe solid was recrystallised from 100 mL water and 50 mL ethanol
5. filtrationfiltered
6. washwashed with 30 mL water
7. customdried in the CAD