HCID 131714770, compound → HCID 11742231, compound

HRID 745214Notes

Reaction equation

HRID 745214 reaction equation
C(O)(=O)C.[Cl:5][C:6]1[C:25]2[C@:20]([CH3:28])([C@H:21]3[CH2:27][C@H:22]3[C:23](=[O:26])[CH:24]=2)[C@@H:19]2[C@H:8]([C@H:9]3[C@:16]([CH3:29])([CH2:17][CH2:18]2)[C@@:12]([OH:30])([C:13](=[O:15])[CH3:14])[CH2:11][CH2:10]3)[CH:7]=1.C(O)(=O)C.[Cl:35]C1C2[C@](C)(CCC(=O)C=2)[C@@H]2[C@H]([C@H]3[C@](C)(CC2)[C@@](O)(C(=O)C)CC3)C=1>>[Cl:35][C:24]1[C:23](=[O:26])[C@@H:22]2[CH2:27][C@@H:21]2[C@@:20]2([CH3:28])[C:25]=1[C:6]([Cl:5])=[CH:7][C@@H:8]1[C@@H:19]2[CH2:18][CH2:17][C@@:16]2([CH3:29])[C@H:9]1[CH2:10][CH2:11][C@:12]2([OH:30])[C:13](=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 131714770HCID 131714770, compoundHCID 131714771HCID 131714771, compound

Product 1

HCID 11742231HCID 11742231, compound

Procedure

Preferred compounds of formula (I) are 6-chloro-17-hydroxy-1α,2α-methylene-pregna-4,6-diene-3,20-dione acetate (cyproterone acetate) and 6-chloro-17-hydroxy-pregna-4,6-diene-3,20-dione acetate (chlormadinone acetate).

Sources & evidence

ORD record
ord-a5efb52dc8c940339b333ee720ed8be8
Source dataset
uspto-grants-1986_07
Patent number
US04598072

Reaction notes

Loading…