Ammonium Chloride → HCID 13882400, compound

Participants

Reaction Steps

To a Gringard reactant prepared from 2.2 g. of magnesium turnings and 25 g. of 4-[(6-methylpyrid-2-yl)-methoxy]-bromobenzene in 120 ml. of dry tetrahydrofurane a solution of 9.1 g. of 4-fluoropropiophenone in 45 ml. of tetrahydrofurane is added dropwise at 0° C. The reaction mixture is stirred at room temperature for two additional hours, and is then decomposed with a saturated aqueous ammonium chloride solution, under cooling. The aqueous phase is extracted with tetrahydrofurane. The tetrahydrofurane phase is washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and evaporated in vacuo. Crystallization of the crude product from a mixture of ethyl acetate and n-hexane yields 15.2 g. of the title compound, melting at 103° to 104° C.

Provenance & Evidence