Morpholine → HCID 13120664, compound

HRID 745227Notes

Reaction equation

HRID 745227 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[N:16]([C:17](=[O:20])[CH2:18]Cl)[CH2:15][CH2:14][NH:13][C:12]2=[O:21])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[N:16]([C:17](=[O:20])[CH2:18][N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[CH2:15][CH2:14][NH:13][C:12]2=[O:21])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 13120662HCID 13120662, compound

Product 1

HCID 13120664HCID 13120664, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7.8 g of the 3-(3,4-dimethoxyphenyl)-4-chloroacetylpiperazin-2-one prepared in accordance with Example 7, 50 ml of toluene and 4.5 g (0.05 mol) of morpholine are boiled under reflux for 3 hours. The reaction mixture is then concentrated in vacuo, an aqueous solution of potassium carbonate is added to the residue and the mixture is extracted by shaking with methylene chloride. The organic phase is separated off and the methylene chloride is removed by evaporation.

Workup

  1. temperatureunder reflux for 3 hours
  2. concentrationThe reaction mixture is then concentrated in vacuo
  3. additionan aqueous solution of potassium carbonate is added to the residue
  4. extractionthe mixture is extracted
  5. customThe organic phase is separated off
  6. customthe methylene chloride is removed by evaporation

Sources & evidence

ORD record
ord-4ec03aa6e9594b6e94204eaa87920272
Source dataset
uspto-grants-1986_07
Patent number
US04598079

Reaction notes

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