Ammonia → HCID 13120681, compound

HRID 745232Notes

Reaction equation

HRID 745232 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[N:11]([C:12](=[O:15])[CH2:13]Cl)[CH2:10][CH2:9][NH:8][C:7]1=[O:16].N.[NH:18]1CCOCC1>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[N:11]([C:12](=[O:15])[CH2:13][NH2:18])[CH2:10][CH2:9][NH:8][C:7]1=[O:16]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 8083MorpholineHCID 23315297HCID 23315297, compound

Product 1

HCID 13120681HCID 13120681, compound

Procedure

Reacting the compound obtained in Example 21 with ammonia or morpholine, as described in Example 7, gives 3-(2-thienyl)-4-aminoacetylpiperazin-2-one: melting point: 130° C. (decomposition), or 3-(2-thienyl)-4-(morpholinomethylcarbonyl)-piperazin-2-one: melting point: 144°-146° C., respectively.

Sources & evidence

ORD record
ord-4757250d545844f1950af705c4e3632f
Source dataset
uspto-grants-1986_07
Patent number
US04598079

Reaction notes

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