Benzene, 1-chloro-3-isocyanato- → HCID 13120683, compound

HRID 745233Notes

Reaction equation

HRID 745233 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[NH:11][CH2:10][CH2:9][NH:8][C:7]1=[O:12].[Cl:13][C:14]1[CH:15]=[C:16]([N:20]=[C:21]=[O:22])[CH:17]=[CH:18][CH:19]=1>C(Cl)Cl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[N:11]([C:21]([NH:20][C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([Cl:13])[CH:15]=2)=[O:22])[CH2:10][CH2:9][NH:8][C:7]1=[O:12]

Participants

4

Reactant 2

HCID 17968Benzene, 1-chloro-3-isocyanato-HCID 65649Piperazinone, 3-(2-thienyl)- (9CI)

Product 1

HCID 13120683HCID 13120683, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

5.5 g (0.03 mol) of 3-(2-thienyl)-piperazin-2-one, prepared in accordance with Example 16, are dissolved in 60 ml of methylene chloride, 4.6 g (0.03 mol) of 3-chlorophenyl isocyanate, dissolved in 20 ml of methylene chloride, are added dropwise and the mixture is stirred for a further 5 hours at room temperature. The reaction product which has been precipitated is filtered off with suction, washed with methylene chloride and dried.

Workup

  1. additionare added dropwise
  2. customThe reaction product which has been precipitated
  3. filtrationis filtered off with suction
  4. washwashed with methylene chloride
  5. customdried

Sources & evidence

ORD record
ord-0169100c16354165be13bbef2dedba60
Source dataset
uspto-grants-1986_07
Patent number
US04598079

Reaction notes

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