Methyl formate → 3-(1-Methylindol-3-yl)-4-formylpiperazin-2-one

HRID 745239Notes

Reaction equation

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]2[NH:16][CH2:15][CH2:14][NH:13][C:12]2=[O:17])=[CH:3]1.[CH:18](OC)=[O:19]>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]2[N:16]([CH:18]=[O:19])[CH2:15][CH2:14][NH:13][C:12]2=[O:17])=[CH:3]1

Participants

Reactant 2

HCID 7865Methyl formate

HCID 13120697HCID 13120697, compound

Product 1

HCID 131206983-(1-Methylindol-3-yl)-4-formylpiperazin-2-one

Procedure

22.9 g (0.1 mol) of 3-(1-methylindol-3-yl)-piperazin-2-one, prepared in accordance with Example 34, are reacted with methyl formate, as described in Example 5.

Sources & evidence

ORD record: ord-b7f982e8bf194b06a5e0cdad5a6b4cb7
Source dataset: uspto-grants-1986_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04598079

Reaction notes

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