2-((2-Ethoxyphenoxy)methyl)oxirane → HCID 13120699, compound

HRID 745240Notes

Reaction equation

HRID 745240 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]2[NH:16][CH2:15][CH2:14][NH:13][C:12]2=[O:17])=[CH:3]1.C(O[C:21]1[CH:31]=[CH:30][CH:29]=[CH:28][C:22]=1[O:23][CH2:24][CH:25]1OC1)C>C(O)CC(C)C>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]2[N:16]([CH2:21][CH:22]([OH:23])[CH2:28][C:21]3[CH:31]=[CH:30][CH:29]=[CH:28][C:22]=3[O:23][CH2:24][CH3:25])[CH2:15][CH2:14][NH:13][C:12]2=[O:17])=[CH:3]1

Participants

4

Reactant 2

HCID 129593792-((2-Ethoxyphenoxy)methyl)oxiraneHCID 13120697HCID 13120697, compound

Product 1

HCID 13120699HCID 13120699, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Conditions

Temperature
120 °C

Procedure

11.5 g (0.05 mol) of 3-(1-methylindol-3-yl)-piperazin-2-one, prepared in accordance with Example 34, are dissolved in 100 ml of isoamyl alcohol, 9.7 g (0.05 mol) of 3-(2-ethoxyphenoxy)-1,2-epoxypropane are added and the mixture is stirred for 5 hours at 120° C. The reaction mixture is evaporated in vacuo, the residue is dissolved in ethyl acetate, and the hydrochloride is precipitated by adding hydrochloric acid in ether. The product is filtered off with suction and dried.

Workup

  1. customThe reaction mixture is evaporated in vacuo
  2. dissolutionthe residue is dissolved in ethyl acetate
  3. customthe hydrochloride is precipitated
  4. additionby adding hydrochloric acid in ether
  5. filtrationThe product is filtered off with suction
  6. customdried

Sources & evidence

ORD record
ord-4fb051def87b47ea8196ae50dc4ce923
Source dataset
uspto-grants-1986_07
Patent number
US04598079

Reaction notes

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