反应详情

To 9.8 g of 4-methoxy-3-methylbenzonitrile, were added 150 ml of carbon tetrachloride, 10 g of NBS, and 0.4 g of BPO. The mixture was heated under reflux for 2.5 hours. The reaction mixture was cooled in ice, filtered from insolubles and concentrated under reduced pressure. The residue was admixed with n-hexane, stirred for 30 minutes, and collected by filtration to yield 9 g of 3-bromomethyl-4-methoxybenzonitrile; m.p. 102°-103° C.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 2.5 hours
3. temperatureThe reaction mixture was cooled in ice
4. filtrationfiltered from insolubles
5. concentrationconcentrated under reduced pressure
6. filtrationcollected by filtration