Morpholine → HCID 178420835, compound

HRID 745267Notes

Reaction equation

HRID 745267 reaction equation
[OH:1][CH:2]([PH:5](=[O:7])[OH:6])[CH2:3][Cl:4].[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1>CO>[OH:1][CH:2]([PH:5](=[O:6])[O-:7])[CH2:3][Cl:4].[NH2+:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 178527059HCID 178527059, compound

Product 1

HCID 178420835HCID 178420835, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of α-hydroxy-β-chloroethylphosphinic acid (1.45 g) in methanol (10 ml), a solution of morpholine (0.87 g) in methanol (10 ml) was added, and the resultant mixture was stirred for 2 hours. After removal of methanol by distillation, there was obtained 2.30 g (98%) of morpholinium α-hydroxy-β-chloroethylphosphinate (Compound No. 12) as a creamy solid.

Workup

  1. customAfter removal of methanol
  2. distillationby distillation

Sources & evidence

ORD record
ord-95781e8f05ce482dbb6de93208ffac8e
Source dataset
uspto-grants-1986_07
Patent number
US04598092

Reaction notes

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