Dimethyl Sulfoxide → 1-{2-[(2-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-1,2,4-triazole

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Reaction Steps

A mixture of 3.2 parts of α-(2,4-dichlorophenyl)-1H-1,2,4-triazole-1-ethanol nitrate, 2.4 parts of 1-chloro-2-(chloromethyl)benzene, 1.5 parts of a sodium hydride dispersion 50%, 70 parts of dimethyl sulfoxide and 63 parts of benzene is stirred for 2.50 hours at room temperature. Water is added and the product is extracted twice with 2,2'-oxybispropane. The extract is washed twice with water and the solvent is removed in vacuo. The residue is crystallized from 2,2'-oxybispropane, yielding 3 parts of 1-{2-[(2-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-1,2,4-triazole; mp. 106.4° C.

Provenance & Evidence