HCID 908572, compound → HCID 1790984, compound

HRID 745306Notes

Reaction equation

HRID 745306 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]1=[CH:15][C:16](=[O:20])[NH:17][C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2.F[B-](F)(F)F.[CH2:26]([O+](CC)CC)[CH3:27]>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]1=[CH:15][C:16]([O:20][CH2:26][CH3:27])=[N:17][C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2

Participants

4

Reactant 2

HCID 908572HCID 908572, compoundHCID 2723982Triethyloxonium tetrafluoroborate

Product 1

HCID 1790984HCID 1790984, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 3.0 g of 9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido(6,1-a)isoquinolin-2,4-dione and 15.0 g of triethyloxonium fluoroborate in 100 ml of dichloromethane is stirred overnight. The reaction mixture is washed with a solution of sodium carbonate. The organic layer is separated and dried over anhydrous sodium sulfate. Evaporation of the solvent gives the title compound, yield 1.8 g.

Workup

  1. washThe reaction mixture is washed with a solution of sodium carbonate
  2. customThe organic layer is separated
  3. dry with materialdried over anhydrous sodium sulfate
  4. customEvaporation of the solvent

Sources & evidence

ORD record
ord-9735da0f61c2473cac24861bfa5ddc0a
Source dataset
uspto-grants-1986_07
Patent number
US04598148

Reaction notes

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