HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethylaniline → HCID 12788130, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethylaniline | HCID 6896 | — |
| Reactant | 2-Chloro-6,7-dihydro-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one | HCID 4678720 | — |
| Reactant | Benzene ethyl acetate | HCID 21583983 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 12788130 | HCID 12788130 | — |
Reaction Steps
A solution of 9,10-dimethoxy-2-chloro-6,7-dihydro-4H-pyrimido(6,1-a)isoquinolin-4-one (2.5 g), 2,6-dimethylaniline (5.0 ml) in butanol (20.0 ml) is heated under reflux for 10 hours. The solvent is evaporated under reduced pressure to give a gummy mass. Chromatography of the gummy mass over silica gel using benzene-ethyl acetate as the eluant gives the required product. The compound is crystallized from methanol, yield 2.0 g, m.p. 297°-299° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04598148 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-f2639135826f4269a72bc2fe79639dfe |
| Source note | uspto-grants-1986_07 |