Phosphorus pentachloride → Ethoxy(4-phenylbutyl)phosphinyl chloride

HRID 745339Notes

Reaction equation

HRID 745339 reaction equation
[CH2:1]([O:3][P:4]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=O)[O:5]CC)[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:20]>C1C=CC=CC=1>[CH2:1]([O:3][P:4]([Cl:20])([CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 13102400Diethyl 4-phenylbutylphosphonate

Product 1

HCID 15591238Ethoxy(4-phenylbutyl)phosphinyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of diethyl(4-phenylbutyl)phosphonate (0.73 g., 2.6 mmole), benzene (10 ml.) and phosphorus pentachloride (1.0 eq.) is refluxed under argon for 30 minutes. The benzene and phosphorus oxychloride are removed in vacuo to give ethoxy(4-phenylbutyl)phosphinyl chloride.

Workup

  1. temperatureis refluxed under argon for 30 minutes
  2. customThe benzene and phosphorus oxychloride are removed in vacuo

Sources & evidence

ORD record
ord-7937bd22f2a943f7a95219da5ebe094a
Source dataset
uspto-grants-1986_07
Patent number
US04598071

Reaction notes

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