Acetic Anhydride → HCID 54079007, compound

HRID 745366Notes

Reaction equation

HRID 745366 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH3:19])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:20](OC(=O)C)(=[O:22])C>C(O)=O>[CH:20]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH3:19])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)=[O:22]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 54216521HCID 54216521, compound

Product 1

HCID 54079007HCID 54079007, compoundYield 68.1%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Ethyl 2-(2-aminothiazol-4-yl)-2-(2-ethoxyethoxyimino)acetate (syn isomer, 11.5 g.), acetic anhydride (8.2 g.) and formic acid (3.7 g.) were treated in a similar manner to that of Example A-(4) to give ethyl 2-(2-formamidothiazol-4-yl)-2-(2-ethoxyethoxyimino)acetate (syn isomer, 8.6 g.).

Sources & evidence

ORD record
ord-7643b9c770f44b8f95ea1286fec414b1
Source dataset
uspto-grants-1986_07
Patent number
US04598147

Reaction notes

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