HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(2-Aminothiazol-4-yl)-2-(2-hydroxyethoxyimino)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ethyl 2-(2-aminothiazol-4-yl)-2-(2-benzoyloxyethoxyimino)acetate | HCID 53954764 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-(2-Aminothiazol-4-yl)-2-(2-hydroxyethoxyimino)acetic acid | HCID 54403470 | 61% |
Reaction Steps
A solution of ethyl 2-(2-aminothiazol-4-yl)-2-(2-benzoyloxyethoxyimino)acetate (syn isomer, 8.5 g.) in a mixture of 1N aqueous sodium hydroxide (35 ml.), methanol (40 ml.) and tetrahydrofuran (40 ml.) was treated in a similar manner to that of Example C-(4) to give 2-(2-aminothiazol-4-yl)-2-(2-hydroxyethoxyimino)acetic acid (syn isomer, 3.3 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04598147 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-ca65f53112c6410583a9ef506a650b77 |
| Source note | uspto-grants-1986_07 |