HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1,2,3,4-Tetrahydroisoquinolin-4-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (Isoquinolin-4-yl)methanol | HCID 12746377 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1,2,3,4-Tetrahydroisoquinolin-4-yl)methanol | HCID 19261463 | — |
Reaction Steps
0.50 mg (3.1 mmol) isoquinolin-4-yl-methanol, 75 mg platinum dioxide and 3.2 mL 1N hydrochloric acid solution were hydrogenated in 50 mL methanol for 4 h at RT under a hydrogen atmosphere at 50 psi. The reaction mixture was filtered and the filtrate was concentrated to dryness by rotary evaporation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829006B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-83d6649fa9da4783a01162a16a2d33a1 |
| Source note | uspto-grants-2014_09 |