HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 54021691, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-Methylimidazole | HCID 1390 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 53729747 | HCID 53729747 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54021691 | HCID 54021691 | 94.9% |
Reaction Steps
Ethyl 2-(2-aminothiazol-4-yl)-2-(4-fluorobenzyloxyimino)-acetate (syn isomer, 25.5 g.), 1-methylimidazole (1.3 g.), 1N sodium hydroxide solution (118.3 ml.), methanol (250 ml.) and tetrahydrofuran (200 ml.) were treated in similar manner to that of Example p-(4) to give 2-(2-aminothiazol-4-yl)-2-(4-fluorobenzyloxyimino)acetic acid (syn isomer, 22.11 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04598147 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-097dd9857c774cf18158a0f644d94bee |
| Source note | uspto-grants-1986_07 |