反应详情

温度

80 °C

235.0 g of isopentyl methanephosphonite are heated to 80° C. under nitrogen, and 0.5 g of tert.-butyl perpivalate is added. 63.9 g of acrolein cyanohydrin acetate and 2.5 g of tert.-butyl perpivalate are added drop-wise, with vigorous stirring at 80° C., within 3 hours. After reaction is complete, 155.2 g of 97.5% pure isopentyl methanephosphonite are distilled out under high vacuum. (Recovery: 95%). 141.8 g of isopentyl (3-acetoxy-3-cyanopropyl)methylphosphinate (yield=96.5%; purity=93.6%) are obtained.

1. addition0.5 g of tert.-butyl perpivalate is added
2. customAfter reaction
3. distillation155.2 g of 97.5% pure isopentyl methanephosphonite are distilled out under high vacuum