HCID 53681348, compound → HCID 13656745, compound

HRID 745474Notes

Reaction equation

HRID 745474 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH:12]=[CH:13][C:14]3[CH2:15][CH2:16][C:17](=[O:20])[NH:18][N:19]=3)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1>COCCO.[Pd]>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][C:14]3[CH2:15][CH2:16][C:17](=[O:20])[NH:18][N:19]=3)=[CH:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 53681348HCID 53681348, compound

Product 1

HCID 13656745HCID 13656745, compoundYield 76.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 80192-MethoxyethanolSolvent

Procedure

A solution of 2.6 g of 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3(2H)-pyridazinone in 100 ml of 2-methoxyethanol containing 0.5 g of 10% Pd/C is shaken under hydrogen atmosphere for 13 hours. The catalyst is filtered, the filtrate is evaporated to dryness, and the residue is crystallized from ethanol to give 2 g of the above product, mp 195°-196° C.

Workup

  1. filtrationThe catalyst is filtered
  2. customthe filtrate is evaporated to dryness
  3. customthe residue is crystallized from ethanol

Sources & evidence

ORD record
ord-1d8dfb355c67429d92df76a05c016c2c
Source dataset
uspto-grants-1986_07
Patent number
US04599332

Reaction notes

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