反应详情

23.2 g of cyclopropylamine are added dropwise, with stirring and cooling in ice, to a solution of 123.9 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-ethoxyacrylate in 250 ml of ethanol. When the exothermic reaction has subsided, the mixture is stirred for a further 1 hour at room temperature, the solvent is removed in vacuo, and the residue is recrystallized from cyclohexane/petroleum ether. 115 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate of melting point 63°-65° C. are obtained.

1. customWhen the exothermic reaction
2. stirringthe mixture is stirred for a further 1 hour at room temperature
3. customthe solvent is removed in vacuo
4. customthe residue is recrystallized from cyclohexane/petroleum ether