1-[2-(2-Methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinyloxy)ethylamino]-2-propanol → Hydrazine hydrate (1:1)

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Reaction Steps

A mixture of 2.0 g of 1-[2-(2-methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinyloxy)ethylamino]-2-propanol obtained in (a) above, 20 ml of hydrazine hydrate and 40 ml of ethanol was refluxed overnight. After removing the solvent under reduced pressure, a solution of the residue in chloroform was washed with water, dried over magnesium sulfate, and concentrated to dryness. To a solution of the residue in ethanol was added hydrogen chloride ether solution. The solvent was evaporated under reduced pressure. A solution of the crude product in 2 ml of ethanol was added dropwise to 20 ml of ether. The resulting precipitate was separated by decantation to give 1.0 g of 1-[2-(2-methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-hydrazino-6-pyridazinyloxy)ethylamino]-2-propanol hydrochloride having a melting point of 173.3° to 174.1° C.

Provenance & Evidence