HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Amino-2-methylpropylthio)-6-chloropyridazine → 1-[2-(2-Methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylthio)ethylamino]-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Amino-2-methylpropylthio)-6-chloropyridazine | HCID 10465952 | — |
| Reactant | 2-[[2-(2-Methoxyethyl)phenoxy]methyl]oxirane | HCID 23313369 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[2-(2-Methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylthio)ethylamino]-2-propanol | HCID 53970841 | 27.9% |
Reaction Steps
A solution of 980 mg of 3-(2-amino-2-methylpropylthio)-6-chloropyridazine and 960 mg of 1-[2-(2-methoxyethyl)phenoxy]-2,3-epoxypropane in 60 ml of methanol was treated in the same way as in Example 1, (b) to give 534 mg of 1-[2-(2-methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylthio)ethylamino]-2-propanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04599333 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-b38039242dca4f84b22e92e360aecbe0 |
| Source note | uspto-grants-1986_07 |