反应详情

18.7 g (0.092 mole) of 2-(oxiranylmethyl)-1H-isoindole-1,3-(2H)-dione are mixed with 17.5 g (0.092 mole) of 3-(1-piperidinylmethyl)-phenol and the resulting mixture heated for 10 minutes to 130° C. After cooling, the reaction mixture is dissolved in 200 ml of chloroform and the organic phase is washed three times in succession with 30 ml of 1N NaOH-solution, then with 30 ml of water and finally with 30 ml of saturated aqueous NaCl-solution. After the organic phase has been dried over Na2SO4, it is concentrated in vacuo. The residue contains the title compound in the form of a viscous oil.

1. temperaturethe resulting mixture heated for 10 minutes to 130° C
2. temperatureAfter cooling
3. washthe organic phase is washed three times in succession with 30 ml of 1N NaOH-solution
4. dry with materialAfter the organic phase has been dried over Na2SO4, it
5. concentrationis concentrated in vacuo