Methyl acetoacetate → HCID 13552997, compound

Participants

Reaction Steps

To a solution of Compound 1a (0.5 mmol) in methanol (5 mL) was added methyl acetoacetate (1.0 mmol) and concentrated ammonium hydroxide (1.0 mmol) and the reaction mixture was refluxed for 4 days. The solvent was removed in vacuo and the residue purified by flash chromatography on silica gel eluted with diethyl ether:hexane (1:1) and trituration with diethyl ether:hexane (1:2) to afford Compound 1b as a white solid (m.p. 173°-175° C.).

Provenance & Evidence