反应详情

To a solution of Compound 2a (7.23 mmol) in carbon tetrachloride (150 mL) was added N-bromosuccinimide (7.5 mmol) and benzoyl peroxide (0.1 g). The solution was heated at reflux and irradiated with 250 watt sunlamp for 2 hours. The cooled reaction mixture was filtered through a pad of silica gel and the silica gel washed with diethyl ether (3×75 mL). The solvent was removed in vacuo and the residue fractionated to afford Compound 2b as a clear oil (b.p. 100°-103° C./0.1 mm).

1. temperatureThe solution was heated
2. temperatureat reflux
3. customirradiated with 250 watt sunlamp for 2 hours
4. customThe cooled reaction mixture
5. filtrationwas filtered through a pad of silica gel
6. washthe silica gel washed with diethyl ether (3×75 mL)
7. customThe solvent was removed in vacuo