HCID 11030090, compound → HCID 70470764, compound

Participants

Reaction Steps

Partially dissolve 3-[2-(4-chlorophenyl)ethylidene]-quinuclidine hydrochloride (0.12 g, 0.5 mmole) in 5 ml of anhydrous methanol and stir under nitrogen atmosphere. Add t-butyl 3,4-epoxybutyrate (0.16 g, 1.0 mmole) and stir at room temperature for three days. Remove methanol in vacuo and purify the residue by preparative thin-layer chromatography on silica gel (acetonitrile: NH4OH, 90:10) to provide the title compound.

Provenance & Evidence