HCID 23313762, compound → HCID 23313727, compound

Participants

Reaction Steps

To a Parr bottle add 9.74 g (0.03 mole) of 2-[3-(4-nitrophenyl)propyl]-1-azabicyclo[2.2.2]octan-3-one hydrochloride, 150 ml of methanol and 0.5 g of 10% palladium on charcoal catalyst (wet with 2-3 ml of water). Place the bottle on a hydrogenator, flush the system three times with hydrogen and pressurize the system to 25 p.s.i. Shake the reaction mixture and follow the reaction by thin-layer chromatography on silica gel (acetonitrile:ammonium hydroxide, 95:5). At the completion of the reaction remove the catalyst by vacuum filtration. Wash the catalyst with methanol, to the filtrate add 5 ml of concentrated hydrochloric acid. Remove the solvent in vacuo to afford the title compound.

Provenance & Evidence