HCID 13971534, compound → HCID 23313724, compound

Participants

Reaction Steps

Hydrogenate 11.2 g (0.03 mole) of 2-[3-(4-chloro-3-nitrophenyl)-3-oxopropyl]-1-azabicyclo[2.2.2]octan-3-one hydrochloride over 1.5 g of 10% palladium on carbon catalyst in 250 ml of ethanol. Follow the progress of the reaction by hydrogen uptake and by thin-layer chromatography. When the reaction is complete remove the catalyst by filtration. To the filtrate add 5 ml of concentrated hydrochloric acid. Remove the solvent in vacuo to give the title compound.

Provenance & Evidence