Sodium → HCID 86740890, compound

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Reaction Steps

To the solution of 0.35 g of sodium in 50 ml of ethanol, 1.2 g of thioacetic acid are added and the mixture stirred for 0.5 hours at room temperature. Then 4.5 g 1-(2-bromopropanoyl)-indoline-2-carboxylic acid ethyl ester are added and the mixture is refluxed for 8 hours. It is cooled to room temperature, evaporated, and the residue partitioned between 30 ml of methylene chloride, 70 ml of diethyl ether and 50 ml of water. The organic layer is dried and evaporated, to yield the 1-(2-acetylthiopropanoyl)-indoline-2-carboxylic acid ethyl ester as an oil.

Provenance & Evidence