Triethyl phosphite → Triethyl 2-phosphonopropionate

HRID 745622Notes

Reaction equation

Br[CH:2]([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:9]([O:11][P:12]([O:16]CC)[O:13][CH2:14][CH3:15])[CH3:10]>>[CH2:9]([O:11][P:12]([CH:2]([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4])([O:13][CH2:14][CH3:15])=[O:16])[CH3:10]

Participants

Reactant 2

HCID 31215Triethyl phosphite

HCID 79040Ethyl 2-bromopropionate

Product 1

HCID 107155Triethyl 2-phosphonopropionate

Procedure

Ethyl 2-bromopropanoate (30.0 g.) and triethylphosphite (70.0 g.) were heated overnight at 150° C. under an air condenser. The resulting crude mixture was purified by distillation, the ethyl 2-(diethylphosphono)propanoate was collected at 66°-68° C. at 0.3-0.5 mm.Hg.

Workup

distillationThe resulting crude mixture was purified by distillation
customthe ethyl 2-(diethylphosphono)propanoate was collected at 66°-68° C. at 0.3-0.5 mm.Hg

Sources & evidence

ORD record: ord-56fab70ca8de426b866c6a012712de69
Source dataset: uspto-grants-1986_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04599361

Reaction notes

Loading…