反应详情

A 300-ml flask was charged with 16.6 g of 4-fluorotoluene, 30.0 g of NBS, 0.5 g of benzoyl peroxide and 150 ml of carbon tetrachloride, and the mixture was refluxed for 2.0 hours. The reaction mixture was cooled to room temperature, and the formed precipitate was removed by filtration and the residual CCl4 solution was washed with dilute alkali and then with water, dried over Na2SO4, and evaporated under reduced pressure to give 28.8 g of crude 4-fluorobenzyl bromide.

1. temperaturethe mixture was refluxed for 2.0 hours
2. customthe formed precipitate was removed by filtration
3. washthe residual CCl4 solution was washed with dilute alkali
4. dry with materialwith water, dried over Na2SO4
5. customevaporated under reduced pressure