Formaldehyde → Methylene-(2-methyl-2-thiophen-3-yl-propyl)-amine

HRID 74564Notes

Reaction equation

HRID 74564 reaction equation
[CH3:1][C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)([CH3:5])[CH2:3][NH2:4].[CH2:11]=O>>[CH2:11]=[N:4][CH2:3][C:2]([CH3:5])([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[CH3:1]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 667224312-Methyl-2-(thien-3-yl)propylamine

Product 1

HCID 58117475Methylene-(2-methyl-2-thiophen-3-yl-propyl)-amine

Procedure

5.8 g (37 mmol) 2-methyl-2-thiophene-3-yl-propylamine and 3.6 mL (44 mmol) formaldehyde were stirred together with 2.0 g molecular sieve (4A powders) overnight at RT. The reaction mixture was filtered and the filtrate was concentrated to dryness by rotary evaporation.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated to dryness by rotary evaporation

Sources & evidence

ORD record
ord-d8cfdf11d9304293b839ea82e9b2ce9f
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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