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HRID745651

反应详情

EQUATION

反应方程式

HRID 745651 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccccc1C(=O)Cl
HCID70276

Benzoyl chloride, 2-methyl-

C8H7ClO

结构：CC(=O)OC[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)C[C@@H]1OC(C)=O
HCID12790164

3',5'-Di-O-acetyl-2'-deoxy-5-fluorouridine

C13H15FN2O7

PRODUCTS

生成物

1
结构：CC(=O)OC[C@H]1O[C@@H](n2cc(F)c(=O)n(C(=O)c3ccccc3C)c2=O)C[C@@H]1OC(C)=O
HCID13189896

未命名化合物

收率 29.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

500 mg of 2'-deoxy-3',5'-di-O-acetyl-5-fluorouridine was dissolved in 5 ml of dry pyridine, and the resulting solution was cooled with ice. To the solution was added 710 mg of 2-methylbenzoyl chloride, and the mixture was allowed to stand at room temperature for 100 minutes. The same procedure as in Example 1 gave 200 mg (yield: 29.5%) of 2'-deoxy-3',5'-di-O-acetyl-5-fluoro-3-(2-methylbenzoyl)uridine as crystals having a melting point of 108° to 109° C. This was identical with the crystals obtained in Example 1 by the mixed examination.

WORKUP

后处理

  1. temperaturethe resulting solution was cooled with ice