HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 745717Generated: October 31, 2026
Pyrrolidine → 2-Methyl-5-(pyrrolidinocarbonyl)thiazole
https://huagongshe.com/reaction/745717
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Ethyl 2-methyl-1,3-thiazole-5-carboxylate | HCID 12808791 | — |
| Product | 2-Methyl-5-(pyrrolidinocarbonyl)thiazole | HCID 23311723 | 78.6% |
Reaction Steps
A mixture of 15.42 g (0.0901 mole) of ethyl 2-methyl-5-thiazolecarboxylate and 12 g pyrrolidine was stirred at 120° C. under a nitrogen atmosphere for 36 hours to give 12.91 g of the title compound, m.p. 71-2°C. (78.6% yield with respect to the ester).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04600025 |
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| Source dataset | uspto-grants-1986_07 |
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| ORD ID | ord-6ecdfc27b4b1403395b47dbf0feb3f54 |
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| Source note | uspto-grants-1986_07 |
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