HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate → methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate | HCID 10243182 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate | HCID 10104433 | — |
Reaction Steps
2.0 g (8.5 mmol) methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate in 70 mL MeOH were combined with 0.30 g Raney nickel and hydrogenated for 2 h in a hydrogen atmosphere. The catalyst was removed by suction filtering and the solution was concentrated by rotary evaporation. The residue was immediately reacted further without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829006B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5ff40530b07748d5b45375c1bd584cf4 |
| Source note | uspto-grants-2014_09 |