HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate → 1,2,2a,5-Tetrahydropyrrolo[4,3,2-de]quinolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate | HCID 10104433 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 1,2,2a,5-Tetrahydropyrrolo[4,3,2-de]quinolin-4(3H)-one | HCID 10442192 | — |
Reaction Steps
1.80 g (8.73 mmol) methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate in 100 mL xylene were refluxed for 30 h. The reaction mixture was evaporated down and purified by flash chromatography. The product-containing fractions were combined and evaporated down.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829006B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-cdbb45a4f8dd41cead89feda40477465 |
| Source note | uspto-grants-2014_09 |