HCID 13655641, compound → HCID 13655651, compound

HRID 745747Notes

Reaction equation

HRID 745747 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([CH2:8][C:9](=[CH2:13])[C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1.C(O)(=S)C.[C:20]([OH:24])(=[S:23])[CH2:21][CH3:22]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([CH2:8][CH:9]([CH2:13][S:23][C:20](=[O:24])[CH2:21][CH3:22])[C:10]([OH:12])=[O:11])=[O:7])=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 13655641HCID 13655641, compoundHCID 178418634HCID 178418634, compoundHCID 178460587HCID 178460587, compound

Product 1

HCID 13655651HCID 13655651, compoundYield 71%

Procedure

Following the procedure of Example 1 using 26.9 g of 3-(4-bromobenzoyl)-2-methylenepropionic acid and 10 ml of thiopropionic acid in place of 19.0 g of 3-benzoyl-2-methylenepropionic acid and 8.0 ml of thioacetic acid, respectively, there was obtained 25.5 g (yield: 71%) of 3-(4-bromobenzoyl)-2-propionylthiomethylpropionic acid as crystals.

Sources & evidence

ORD record
ord-f35767e794134c8e91efce898634484c
Source dataset
uspto-grants-1986_07
Patent number
US04600540

Reaction notes

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