HCID 11832841, compound → HCID 13454956, compound

Participants

Reaction Steps

A mixture of 5-bromo-6-methoxy-1-naphthalenecarboxylic acid (33.35 g, 0.11 moles, described in example 1b) in glacial acetic acid (460 ml) and 47% aqueous HBr(417 ml) was heated at reflux for 9 hr. The resulting precipitate was collected, washed with water and dried over P2O5 under reduced pressure. The precipitate was recrystallized from ethanol-water to give 21.45 g of 5-bromo-6-hydroxy-1-naphthalenecarboxylic acid; mp>225° C.; NMR (DMSO-d6)δ 8.0 (m, 5H), 11.0 (broad, 1H), 12.6 (broad, 1H).

Provenance & Evidence