HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroisonicotinic acid → HCID 58386429, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroisonicotinic acid | HCID 236985 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 5-Fluoro-3,3-dimethylindoline | HCID 21712575 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58386429 | HCID 58386429 | — |
Reaction Steps
0.17 g (1.1 mmol) 2-chloroisonicotinic acid, 0.18 g (1.1 mmol) 5-fluoro-3,3-dimethyl-2,3-di-hydro-1H-indole, 0.28 mL (2.0 mmol) TEA and 3.0 mL DMF were combined with 0.39 g (1.2 mmol) TBTU and stirred overnight at RT. The reaction mixture was purified by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829006B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-3b54a2a32d7b4fdabb852dd2b5818b90 |
| Source note | uspto-grants-2014_09 |