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1-Pentanol → Phthalimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Pentanol | HCID 6276 | — |
| 反応物 | 4-(Aminosulfonyl)-5-chlorophthalimide | HCID 19733 | — |
| 反応物 | 4-Amino-1-[4-(2-propenyloxy)benzyl]piperidine | HCID 23312445 | — |
| 生成物 | Phthalimide | HCID 6809 | — |
反応手順
Reaction of 4-chloro-5-sulfamoylphthalimide (4.54 g., 0.0174 mole) and 4-amino-1-[4-(2-propenyloxy)benzyl]piperidine (4.29 g., 0.0174 mole) in 100 ml. of n-pentanol at reflux temperature for 24 hrs. according to the procedure of Example 1(a) afforded crude 1,3-dioxoisoindole product. Purification was carried out by treating with methanol-decolorizing charcoal followed by trituration with ether to afford 4.8 g. (57%) of the 1,3-dioxoisoindole used without further purification below.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04600758 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-93f67a613d834704a939bf4a90a003e9 |
| 出典メモ | uspto-grants-1986_07 |