反应详情

Cyclododecanone (0.91 gram, 5 mmol) was added to a solution of 2-aminomethyl-2-hydroxyadamantane (0.90 gram, 5 mmol) in 30 ml toluene. After the mixture was refluxed (Dean-Stark separator) for 7 hours, the solvent was evaporated leaving derivative VIII as a brown oil which crystallized from isopropanol, Yield--1.08 gram melting point 241°-245° C. (white crystals from isopropanol).

1. temperatureAfter the mixture was refluxed (Dean-Stark separator) for 7 hours
2. customthe solvent was evaporated