Cyclododecanone → HCID 13650426, compound

HRID 745855Notes

Reaction equation

HRID 745855 reaction equation
[C:1]1(=[O:13])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:14][CH2:15][C:16]1(O)[CH:23]2[CH2:24][CH:19]3[CH2:20][CH:21]([CH2:25][CH:17]1[CH2:18]3)[CH2:22]2>C1(C)C=CC=CC=1>[C:1]12([NH:14][CH2:15][C:16]3([CH:23]4[CH2:22][CH:21]5[CH2:20][CH:19]([CH2:18][CH:17]3[CH2:25]5)[CH2:24]4)[O:13]1)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2

Participants

4

Reactant 2

HCID 13246CyclododecanoneHCID 2866492-Aminomethyl-adamantan-2-ol

Product 1

HCID 13650426HCID 13650426, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Cyclododecanone (0.91 gram, 5 mmol) was added to a solution of 2-aminomethyl-2-hydroxyadamantane (0.90 gram, 5 mmol) in 30 ml toluene. After the mixture was refluxed (Dean-Stark separator) for 7 hours, the solvent was evaporated leaving derivative VIII as a brown oil which crystallized from isopropanol, Yield--1.08 gram melting point 241°-245° C. (white crystals from isopropanol).

Workup

  1. temperatureAfter the mixture was refluxed (Dean-Stark separator) for 7 hours
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-ab6d4767650e4c3685387bd930d8ca48
Source dataset
uspto-grants-1986_07
Patent number
US04600782

Reaction notes

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