Chloroacetyl chloride → HCID 13375745, compound

Participants

Reaction Steps

8 cc of chloroacetyl chloride are added, with stirring, to a mixture consisting of 9.5 g of methyl 7-amino-3-propyl-4'-flavonecarboxylate made according to Example 7a, 1 liter of benzene and 9 g of anhydrous K2CO3. The mixture is heated to reflux of the benzene for 2 hours, then cooled. The benzene phase is washed with water. A precipitate is formed which is filtered and dissolved in chloroform. The benzene and chloroform phases are evaporated. Methyl 7-(2-chloracetamido)-3-propyl-4'-flavonecarboxylate is obtained with a yield of 80%. MP=162° C.

Provenance & Evidence