反应详情

1.2 g (4.2 mmol) 1-benzenesulphonyl-2-ethyl-1H-indole in 10 mL EtOH were combined with 5 mL of a (20 mmol) 4 N aqueous sodium hydroxide solution and refluxed for 8 h. Then the solvent was eliminated using the rotary evaporator and the residue was diluted with ice water. After acidifying with semi-concentrated aqueous hydrochloric acid the grease precipitated was extracted with ethyl acetate. The organic phase was dried on sodium sulphate, filtered off, evaporated down and dried.

1. temperaturerefluxed for 8 h
2. customthe rotary evaporator
3. additionthe residue was diluted with ice water
4. customprecipitated
5. extractionwas extracted with ethyl acetate
6. customThe organic phase was dried on sodium sulphate
7. filtrationfiltered off
8. customevaporated down
9. customdried