Diethyl 2-benzylpropanedioate → HCID 12020975, compound

HRID 745902Notes

Reaction equation

HRID 745902 reaction equation
C(C(C(OCC)=O)C(OCC)=O)C1C=CC=CC=1.[CH2:19]([C:26]([C:35]([O:37][CH2:38][CH3:39])=[O:36])([CH2:32][C:33]#[CH:34])[C:27]([O:29][CH2:30][CH3:31])=[O:28])[C:20]1C=CC=[CH:22][CH:21]=1.BrCC#CC.C(C(C(OCC)=O)(CC#CC)C(OCC)=O)C1C=CC=CC=1>>[C:35]([C:26]([CH2:32][C:33]#[CH:34])([CH2:19][CH2:20][CH2:21][CH3:22])[C:27]([O:29][CH2:30][CH3:31])=[O:28])([O:37][CH2:38][CH3:39])=[O:36]

Participants

5

Reactant 4

HCID 69090Diethyl 2-benzylpropanedioate2×HCID 27568621-Bromo-2-butyneHCID 10637085HCID 10637085, compoundHCID 23311056HCID 23311056, compound

Product 1

HCID 12020975HCID 12020975, compound

Procedure

Proceeding similarly, but replacing diethyl n-butylmalonate with diethyl benzylmalonate, ethyl 2-benzyl-2-carboethoxypent-4-ynoate was prepared. Also by replacing diethyl n-butylmalonate with diethyl benzylmalonate, replacing propargyl bromide with 1-bromo-2-butyne, ethyl 2-benzyl-2-carboethoxyhex-4-ynoate was prepared.

Workup

  1. customwas prepared
  2. customwas prepared

Sources & evidence

ORD record
ord-124eeaa7d5e14789ba80c0a4d85db021
Source dataset
uspto-grants-1986_07
Patent number
US04602006

Reaction notes

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