HCID 13656160, compound → HCID 13656162, compound

HRID 745908Notes

Reaction equation

HRID 745908 reaction equation
C(OC([NH:11][CH2:12][CH:13]([OH:40])[CH2:14][CH2:15][CH:16]([NH:27][CH:28]([C:37]([OH:39])=[O:38])[CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:17]([N:19]1[CH2:26][CH2:25][CH2:24][C@H:20]1[C:21]([OH:23])=[O:22])=[O:18])=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:11][CH2:12][CH:13]([OH:40])[CH2:14][CH2:15][CH:16]([NH:27][CH:28]([C:37]([OH:39])=[O:38])[CH2:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:17]([N:19]1[CH2:26][CH2:25][CH2:24][C@H:20]1[C:21]([OH:23])=[O:22])=[O:18]

Participants

4

Reactant 1

HCID 13656160HCID 13656160, compound

Product 1

HCID 13656162HCID 13656162, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Compound VII in ethanol was hydrogenated at 40 psi at room temperature for 24 hours using 10% Pd/C. Filtration, purification over LH-20 and freeze drying gave VIII.

Workup

  1. filtrationFiltration, purification over LH-20
  2. customfreeze drying

Sources & evidence

ORD record
ord-237f8868d3594245b728a7c689803a9f
Source dataset
uspto-grants-1986_07
Patent number
US04602002

Reaction notes

Loading…